Examine

Welcome to the Examine page, this is where I keep all the studies I have individually read, critiqued, taken notes on, and for each I have created a video. This library is rich with topics from skin care, fasting, nutrition, and many other subjects. Enjoy.

Tadalafil (Cialis) on Testosterone and Erectile Dysfunction

This analysis uncovers how tadalafil affects testosterone and erectile dysfunction.

Collagen for Skin Aging.

This investigation covers 11 studies to determine the effect of collagen supplementation on skin anti-aging effects.

[S18, 144-146] OMAD on Health

This series of 4 studies investigates the role One Meal a Day has on several indices of health.

[S130-137] Nitrates on Blood Pressure

This investigation pulls together 7 studies to find out if nitrates can actually benefit our high blood pressure.

[S123-129] Does Fish Oil (Omega-3) improve Brain Performance?

This analysis looks into the effects of omega-3 supplementation on mild cognitive decline - can it reverse these effects and prevent dementia?

[S138-143] Carbohydrate-Insulin Model vs Conventional Model of Obesity

This investigation pulls together several reviews and meta-analyses to compare to prevailing models of obesity.

[S109-116, 120-122] Hyaluronic Acid on Reversing Skin Aging.

This investigation covers a number of studies to find out if hyaluronic acid can reverse or slow skin aging.

[S117, 118, 119] GlyNAC on Age Reversal

These studies investigate how supplementation with GlyNAC may reverse several aspects of aging.

[S75] The pathophysiology of hypertension in patients with obesity.

This scientific review covers the literature relating obesity to hypertension.

[S74, 77, 83, 86, 88, 90] Long Term Sucralose Consumption on Insulin Resistance.

These studies look at the effect of sucralose consumption over weeks and months on insulin resistance measures.

[S82, 84, 85, 87, 89] One Dose Sucralose on Insulin Sensitivity

These studies look at the effect of one bolus of sucralose on blood glucose levels and insulin levels to find the effect on insulin sensitivity.

[S92] Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing

This scientific review covers the physiological interactions between fat tissue and muscle tissue, especially in sarcopenia (age related muscle loss).

[S71] The Metabolic Role and Therapeutic Potential of the Microbiome

This scientific review covers everything on the microbiome and your overall health, from effects to mechanisms.

[S91] Mitochondrial Impairment in Sarcopenia

This review looks at the current evidence linking mitochondrial dysfunction to sarcopenia.

[S77] Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial

This study investigates how sucralose affects insulin sensitivity in healthy adults.

[S78] Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction

This study investigates the effectiveness of Korean Red Ginseng as a potential therapeutic for erectile dysfunction.

[S83] A 12-week randomized clinical trial investigating the potential for sucralose to affect glucose homeostasis

This study investigates the effect sucralose might have on blood glucose tolerance.

[S81] Sweet Taste Receptor Expressed in Pancreatic b-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion

This study investigates the role sweet taste receptors and the use of saccharin and acesulfame-K on insulin secretion.

[S80] Effects of aspartame-, monk fruit-, stevia- and sucrose-sweetened beverages on postprandial glucose, insulin and energy intake

This study investigates how a single exposure to 3 non-nutritive sweeteners affects blood sugar, blood insulin, and food consumption over a 24 hour period.

[S79] Aspartame Consumption for 12 Weeks Does Not Affect Glycemia, Appetite, or Body Weight of Healthy, Lean Adults in a Randomized Controlled Trial

This study investigates the role aspartame has on insulin resistance in healthy, normal weight individuals.

[S76] A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults

This study investigates what role alternate day fasting (ADF) has on weight loss, metabolism, and health, when calorie deficit is the same.

[S74] Effects of sucralose on insulin and glucagon-like peptide-1 secretion in healthy subjects: a randomized, double-blind, placebo-controlled trial

This study investigates the role sucralose has on insulin sensitivity and glucagon-like peptide in healthy, normal weight individuals.

[S67] A Periodic Diet that Mimics Fasting Promotes Multi- System Regeneration, Enhanced Cognitive Performance, and Healthspan

This study investigates the effects of a Fasting Mimicking Diet on many physiological and molecular health outcomes.

[S55] Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity in a clinical trial of normal-weight individuals

This study investigates the role a 5 day water fast has on health.

[S49] Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes

Caffeine's role in high intensity performance, including lifting, stratified based on CYP gene expression - slow vs fast metabolizers of caffeine.

[S45] CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance

This study investigates the role caffeine metabolism genes have on resistance training performance.

[S41] Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans

This study investigates how over 24 hours of exposure to an almost pure monounsaturated, polyunsaturated, or saturated fat drink (every hour) affects insulin sensitivity.

[S42] Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity

This study investigates how saturated and polyunsaturated fat focused diets affect insulin sensitivity and fat distribution.

[S69] Human Beta Cell Regenerative Drug Therapy for Diabetes: Past Achievements and Future Challenges

This scientific review looks over all the available studies on regenerating the pancreas in diabetic individuals.

[S39] Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

This study investigates how saturated and unsaturated fats affect pancreatic beta cells and insulin secretion.

[S37] A high-fat, high-saturated fat diet decreases insulin sensitivity without changing intra-abdominal fat in weight-stable overweight and obese adults

This study investigates how a high fat, high saturated fat diet compares against a low fat, low saturated fat diet on measures of insulin sensitivity.

[S45] CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance

This study investigates the role caffeine metabolism genes have on resistance training performance

[S44] Effects of Acute caffeine ingestion on resistance training performance and perceptual responses during repeated sets to failure

This study investigates the effect of caffeine consumption on resistance training performance.

[S38] Diets High in Protein or Saturated Fat Do Not Affect Insulin Sensitivity or Plasma Concentrations of Lipids and Lipoproteins in Overweight and Obese Adults

This study investigates the impact protein (and saturated fats) have on insulin sensitivity.

[S48] The effect of caffeine ingestion on 8 km run performance in a field setting

This study investigates the role caffeine has on endurance performance measured by running.

[S47] Caffeine has a small effect on 5-km running performance of well-trained and recreational runners

This study investigates the role caffeine has on endurance performance measured by running.

[S46] The effects of different doses of caffeine on endurance cycling time trial performance

This study investigates the role caffeine has on endurance performance measured by cycling.

[S40] Reprogramming of fatty acid metabolism in cancer

This review pulls together the literature on how fat related enzymes and fat, itself, affect cancer.

[S34] A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration

This study investigates the effects various amounts of carbohydrates have on mitochondrial respiration (energy production) in fat cells.

[31] Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans

This study investigates how saturated fat differently affects overweight and lean individuals' insulin sensitivity.

[S35] Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial

This study investigates the effect of carbohydrate consumption on metabolism.

[S32] Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

This review investigates the role nutrition (over and under nutrition) affect mitochondrial behavior.

[S30] Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle

This study investigates how the consumption of saturated fat or unsaturated fat affects insulin sensitivity in the muscle of people.

[S28] Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

This study investigates the effect of saturated fat and unsaturated fat on insulin signaling, as well as mitochondrial function, in isolated muscle cells.

[27] Protection from Palmitate-Induced Mitochondrial DNA Damage Prevents from Mitochondrial Oxidative Stress, Mitochondrial Dysfunction, Apoptosis, and Impaired Insulin Signaling in Rat L6 Skeletal Muscle Cells

This study investigates the role saturated fat (palmitate) has on mitochondrial function and insulin signaling in muscle cells.

[S26] Multiple pathways are involved in palmitic acid-induced toxicity

This study aims to show the effects of saturated fat palmitate on various markers of cell health

[S25] Metabolic regulation of mitochondrial dynamics

This review compiles all the research (up to 2016) on mitochondrial behavior and regulation in the context of metabolism.

[S20] Metabolism of a-linolenic acid in humans

This study investigates how alpha-linolenic acid (ALA) is metabolized when consumed.

[S23] Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes

This study investigates where peroxisomes originate.

[S21] Ketones Elicit Distinct Alterations in Adipose Mitochondrial Bioenergetics

This study investigates how ketones (and the ketogenic diet) affects fat tissue mitochondria.